Welcome

Welcome

to the homepage of

Wolfgang Beyer

Dr. med. vet. habil.


Acad. Dir. rtd.

Specialist Veterinary Microbiology and Immunology

Selected publications

 

 Contributions to books

 

 

  1. Bacillus spp., in: Mikrobiologische Diagnostik, 2. Auflage, 2009, Hrsg.: B. Neumeister, H. K. Geiss, R. W. Braun, P. Kimmig., S. 386-397, ISBN: 978-3-13-743602-7
  2. In: Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik, MIQ 26: Hochpathogene Erreger/Biologische Kampfstoffe. Kapitel:Bacillus anthracis (Milzbrand), Wolfgang Beyer, Carsten Bartling, Heinrich Neubauer. ELSEVIER, MIQ 26, 2008, Teil I, S. 38-55.
  3. In: Anthrax in Humans and Animals, 4th edition. WHO 2008, ISBN 978-92-4-154753-6.
  4. In: Bartling, C., W. Beyer, H. Neubauer (2006): Bacillus anthracis: Anthrax – Jack out of Pandora’s box. Infektiologie – Aktuelle Aspekte, Jahrbuch 2006, Kommissionsverlag der ÖVG C. & E. Dworak GmbH, ISBN 3-7067-0024-7, S. 141-153.

 

 Publications in peer reviewed journals

  

  1. Holzer, K., Wareth, G., El-Diasty, M., Abdel-Hamid, N. H., Hamdy, M. E. R., Moustafa, S. A., Linde, J., Bartusch, F., Abdel-Glil, M. Y., Sayour, A. E., Elbauomy, E. M., Elhadidy, M., Melzer, F., & Beyer, W. (2022): Tracking the distribution, genetic diversity and lineage of Brucella melitensis recovered from humans and animals in Egypt based on core-genome SNP analysis and in silico MLVA-16. Transboundary and Emerging Diseases, 69 (6), 3952-3963. https://doi.org/10.1111/tbed.14768.

  2. Braun P, Beyer W, Hanczaruk M, Riehm JM, Antwerpen M, Otterbein C, Oesterheld J, Grass G: Reoccurring bovine anthrax in Germany on the same pasture after 12 years (2022): J. Clinic. Microbiol., 60 (3),e02291-21. https://doi.org/10.1128/jcm.02291-21.

  3. Holzer, K.; El-Diasty, M.; Wareth, G.; Abdel-Hamid, N.H.; Hamdy, M.E.R.; Moustafa, S.A.; Linde, J.; Bartusch, F.; Sayour, A.E.; Elbauomy, E.M.; Elhadidy, M.;Melzer, F.; Beyer, W. (2021): Tracking the Distribution of Brucella abortus in Egypt Based on Core Genome SNP Analysis and In Silico MLVA-16. Microorganisms, 9, 1942. https://doi.org/10.3390/microorganisms9091942.

  4. Wareth G, El-Diasty M, Abdel-Hamid NH, Holzer K, Hamdy MER, Moustafa S, Shahein MA, Melzer F, Beyer W, Pletz MW, Neubauerr H (2021): Molecular characterization and antimicrobial susceptibility testing of clinical and non-clinical Brucella melitensis and Brucella abortus isolates from Egypt. One Health, 13, org/10.1016/j.onehlt.2021.100255.

  5. Jauro S, Ndumnego OC, Ellis D, Buys A, Beyer W, Heerden Hv (2020): Immunogenicity and Protective Efficacy of a Non-Living Anthrax Vaccine versus a Live Spore Vaccine with Simultaneous Penicillin-G Treatment in Cattle. Vaccines, 8, 595; doi:10.3390/vaccines8040595.

  6. Jauro S, Ndumnego OC, Ellis CE, Buys A, Beyer W, van Heerden H (2020): Immunogenicity of Non-Living Anthrax Vaccine Candidates in Cattle and Protective Efficacy of Immune Sera in A/J Mouse Model Compared to the Sterne Live Spore Vaccine. Pathogens 2020, 9, 557; doi:10.3390/pathogens9070557.

  7. Finke EJ, Beyer W, Loderstädt U, Frickmann H (2020): Review: The risk of contracting anthrax from spore-contaminated soil – A military medical perspective. Eur. J. Microbiol. Immunol. https://doi.org/10.1556/1886.2020.00008.

  8. Huber I, Potapova K, Ammosova E, Beyer W, Blagodatskiy S, Desyatkin R, Hoelzle LE, Ignateva M, Kokolova L, Lemke S, Neustroev M, Nyukkanov A, Protodyakonova G, Reshetnikov A, Romig T, Shadrin V, Samoilova I, Semenov S, Stepanov K, Tarabukina N, Vinokurova L, Zakharova, R Nifontov K (2020): Symposium report: emerging threats for human health – impact of socioeconomic and climate change on zooanthroponosis in the Republic of Sakha (Yakutia), Russia. International Journal of Circumpolar Health 79:1; DOI: 10.1080/22423982.2020.1715698.

  9. Antwerpen M, Beyer W, Bassy O, Ortega‐García MV, Cabria‐Ramos JC, Grass G, Wölfel R (2019): Phylogenetic Placement of Isolates Within the Trans‐Eurasian Clade A.Br.008/009 of Bacillus anthracis. Microorganisms 7:689; doi:10.3390/microorganisms7120.
  10. Ndumnego OC, Koehler SM, Crafford JE, Beyer W, vanHeerden H (2018): Immunogenicity of anthrax recombinant peptides and killed spores in goats and protective efficacy of immune sera in A/J mouse model. ScientificReports, 8:16937.
  11. Lienemann T, Beyer W, Pelkola K, Rossow H, Rehn A, Antwerpen M, Grass G (2018): Bacillus anthracis isolates from Finland, a country with rare anthrax cases. BMC Microbiology, 18:102.
  12. Basson L, Hassim A, Dekker A, Gilbert A, Beyer W, Rossouw J, Van Heerden H (2018): Blowflies as vectors of Bacillus anthracis in the Kruger National Park, Koedoe 60(1), a1468.
  13. Huber I, Potapova K, Kuhn A, Schmidt H, Hinrichs J, Rohde C, Beyer W (2018): 1st German Phage Symposium-Conference Report. Viruses,10, pii: E158. doi: 10.3390/v10040158. IF 3,7 in 2017.
  14. Phaswana PH, Ndumnego OC, Koehler SM, Beyer W, Crafford JE, van Heerden H (2017): Use of the mice passive protection test to evaluate the humoral response in goats vaccinated with Sterne 34F2 live spore vaccine. BMC Vet Res 48:46. DOI 10.1186/s13567-017-0451-4. IF 2,07 in 2016.
  15. Koehler SM, Buyuk F, Celebi O, Demiraslan H, Doganay M, Sahin M, Moehring J, Ndumnego OC, Otlu S, van Heerden H. and Beyer W. (2017): Protection of farm goats by combinations of recombinant peptides and formalin inactivated spores from a lethal Bacillus anthracis challenge under field conditions.  BMC Veterinary Research 13:220. IF 2,07 in 2016.
  16. Ndumnego OC, Köhler SM, Crafford C, vHeerden H, Beyer W (2016): Comparative analysis of the immunologic response induced by theSterne 34F2 live spore Bacillus anthracis vaccine in a ruminant model. Vet Immunol  Immunop 178:14–21. IF1,66 in 2015.
  17. Turner WC, Kausrud KL, Beyer W, Easterday WR, Barandongo ZR, Blaschke E, Cloete CC, Lazak J, Van Ert MN, Ganz HH, Turnbull PCB, Stenseth NC, Getz WM (2016): Lethal exposure: An integrated approach to pathogen transmission via environmental reservoirs. Scientific Reports, 6:27311. DOI: 10.1038/srep27311. IF5,23 in 2015.
  18. Köhler, S.M., Baillie, L.W., Beyer, W. (2015): BclA and toxin antigens augment each other to protect NMRI mice from lethal Bacillus anthracis challenge. Vaccine 33, 2771–2777. IF3,5 in 2015.
  19. Hardes K., Becker G., Lu Y., Dahm S.O., Köhler S., Beyer W., Sandvig K., Yamamoto H., Lindberg I., Walz L., von Messling V., E. Than M.E., Garten W., Steinmetzer T. (2015): Novel furin inhibitors with potent anti-infectious activity. ChemMedChem. DOI: 10.1002/cmdc.201500103. IF3,05 in 2015.
  20. Klumpp J., Schmuki M., Shanmuga S., Beyer W., Fouts D.E., Bernbach V., Calendar R., Loessner M.J. (2014): The odd one out: Bacillus ACT bacteriophage CP-51exhibits unusual properties compared to related Spounavirinae W.Ph.and Bastille.Virology 462-463, 299–308. IF3.28 in 2015.
  21. Ganz HH, Law C, Schmuki M, Eichenseher F, Calendar R, Loessner MJ, Wayne MG, Korlach J, Beyer W, Klumpp J (2014): Novel Giant Siphovirus from Bacillus anthracis Features Unusual Genome Characteristics. PLoS ONE 9(1): e85972. doi:10.1371/journal.pone.0085972. IF3,53 in 2015.
  22. Ndumnego, O.C., Crafford, J., Beyer W., and van Heerden H. (2014): Quantitative anti-PA IgG ELISA; assessment and comparability with the anthrax toxin neutralization assay in goats. BMC Veterinary Research 2013, 9:265  doi:10.1186/1746-6148-9-265. IF1,74 in 2014.
  23. von Terzi B, Turnbull PCB, Bellan SE, Beyer W (2014): Failure of Sterne- and Pasteur-Like Strains of Bacillus anthracis to Replicate and Survive in the Urban Bluebottle Blow Fly Calliphora vicina under Laboratory Conditions. PLoS ONE 9(1): e83860. doi:10.1371/journal.pone.0083860. IF3,5 in 2013.
  24. Beyer, W. and Turnbull, P.C.B. (2013): Co-infection of an animal with more than one genotype can occur in anthrax. Letters in Applied Microbiology 57:380-4. doi: 10.1111/lam.12140 doi:10.1111/lam.12140. IF 1,75 in 2013.
  25. Bellan, S.E., Turnbull, P.C.B., Beyer, W. and Getz, W. M. (2013): Effects of experimental exclusion of scavengers from carcasses of anthraxs-infected herbivores on Bacillus anthracis sporulation, survival, and distribution. Appl. Environ. Microbiol., 79(12):3756. DOI: 10.1128/AEM.00181-13. IF3,95 in 2013.
  26. Grunow R, Klee SR, Beyer W, George M, Grunow D, Barduhn A, Klar S, Jacob D, Elschner M, Sandven P, Kjerulf A, Jensen JS, Cai W, Zimmermann R, Schaade L. (2013): Anthrax among heroin users in Europe possibly caused by same Bacillus anthracis strain since 2000. Euro Surveill., 18:pii=20437. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20437. IF4,66 in 2013.
  27. Owen, M.P., Schauwers, W., Hugh-Jones, M.E., Kiernan, J.A., Turnbull P.C.B., Beyer, W. (2013): A simple, reliable M'Fadyean stain for visualizing the Bacillus anthracis capsule. J. Microbio. Meth., 92: 264-269. Online available at: http://dx.doi.org/10.1016/j.mimet.2013.01. IF2,1 in 2013.
  28. Milhomme, O., Koehler, S.M., Ropartz, D., Lesur, D., Pilard, S., Djedaïni-Pilard, F., Beyer, W., and Grandjean, C. (2012): Synthesis and immunochemical evaluation of a non-methylated disaccharide analogue of the anthrax tetrasaccharide. Org. Biomol. Chem., 10, 8524. doi: 10.1039/c2ob26131f. IF3,57 in 2012.
  29. Beyer W., Bellan S., Eberle G., Ganz H.H., Getz W.M., Haumacher R, Hilss K.A., Kilian W., Lazak J., Turner W.C., Turnbull P.C.B. (2012): Distribution and Molecular Evolution of Bacillus anthracis Genotypes in Namibia. PLoS Negl Trop Dis 6(3): e1534. doi:10.1371/journal.pntd.0001534. IF4,57 in 2012.
  30. Sting, R., B. Wagner, A. Sari-Turan, M. Stermann, M. Reule, M. Eichner, W. Beyer (2012): Serological studies on Coynebacterium pseudotuberculosis infections in goats in Baden-Wuerttemberg (Germany) and seroreactions on antigens used for newly developed Enyme-Linked Immunosorbent Assays (ELISA). BMTW 125:67-75. IF0,89 in 2012.
  31. Welkos, S., Cote, C.K., Hahn, U.,  Shastak, O., Jedermann, J., Bozue, J.,Jung, G., Ruchala, P., Pratikhya, P., Tang, T., Lehrer, R.I., W. Beyer (2011): Humanized q-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections. Antimicrobial Agents and Chemotherapy, 55(9):4238-4250. IF4,84 in 2011.
  32. Vor dem Esche, U., M. Huber, A. Zgaga-Griesz, R. Grunow, W. Beyer, U. Hahn, W. G. Bessler (2011): Passive vaccination with a human monoclonal antibody: Generation of antibodies and studies for efficay in Bacillus anthracis infections. Immunobiology, 216:847-53. IF3,2 in 2011.
  33. Akinyemi, K. O., W. Philipp, W. Beyer, R. Böhm (2010): Application of phage typing and pulsed-field gel electrophoresis to analyse Salmonella enterica isolates from a suspected outbreak in Lagos, Nigeria.  J Infect Dev Ctries, 4(12): 828-834. IF1,2 in 2011.
  34. Beyer, W., P.C.B. Turnbull (2009): Review – Anthrax in animals. JMAM, 30, p. 481-489, ISSN: 0098-2997. IF10,7.
  35. Lasch, P., W. Beyer, H. Nattermann, M. Stämmler, E. Siegbrecht, R. Grunow, D. Naumann (2009): Identification of Bacillus anthracis by using matrix-assisted laser desorption ionization-time of flight mass spectrometry and artificial neural networks. Appl. Environ. Microbiol. 75:7229-7242. IF3,69 in 2009.
  36. Hadjinicolaou, A. V., V. L. Demetriou, J. Hezka, W. Beyer, T. L. Hadfield, L. G. Kostrikis (2009): Use of molecular beacons and multi-allelic real-time PCR for detection of and discrimination between virulent Bacillus anthracis and other Bacillus isolates. J. Microbiol. Meth. 78:45–53. IF2,43 in 2009.
  37. Hudson, M. J., W. Beyer, R. Böhm, A. Fasanella, G. Garofolo, R. Golinski, P. L. Goossens, U. Hahn, B. Hallis, A. King, M. Mock, C. Montecucco, A. Ozin, F. Tonello, S. H. E. Kaufmann (2008): Bacillus anthracis: Balancing innocent research with dual-use potential. IJMM, 298:345-364. IF3,49 in 2008.
  38. Grunow, R., M. Porsch-Özcürümez, W. Splettstösser, A. Beckendahl, U. Hahn, W. Beyer, R. Böhm, M. Huber, U. vd. Esche, W. Bessler, D. Frangoulidis, E.J. Finke (2007): Monitoring of ELISA-reactive antibodies against anthrax protective antigen (PA), lethal factor (LF), and toxin-neutralising antibodies in serum of individuals vaccinated against anthrax with the PA-based UK anthrax vaccine. Vaccine, 25:3679-3683. IF3,38 in 2007.
  39. Akinyemi K. O., W. Philipp, W. Beyer, R. Böhm (2007). In vitro antimicrobial susceptibility patterns of Salmonella enterica serovars and emergence of S. typhimurium phage type DT071 in a suspected community-associated outbreak in Lagos, Nigeria. J. Infect. Developing Countries, 1: 48. IF1,2 in 2011.
  40. Hahn, U., M. Aichler, R. Boehm, W. Beyer (2006): Comparison of the immunological memory after DNA vaccination and protein vaccination against anthrax in sheep. Vaccine, 24:4595-4597. IF3,16 in 2006.
  41. Hahn, U., R. Böhm, W. Beyer (2006): DNA vaccination against anthrax in mice – combination of anti-spore and anti-toxin components. Vaccine, 24:4569-4571. IF3,16 in 2006.
  42. Tomaso, H., C. Bartling, S. Al Dahouk, R.M. Hagen, H.C. Scholz, W. Beyer, H. Neubauer (2006): Growth characteristics of Bacillus anthracis compared to other Bacillus spp. on the selective nutrient media Anthrax Blood Agar® and Cereus Ident Agar®. Syst. Appl. Microbiol., 29:24-26. IF2,04 in 2006.
  43. Beyer W. (2004). Impfstrategien zur Milzbrandprophylaxe. Berl. Münchn. Tierärztl. Wschr. (BMTW), 117:508-524.
  44. Hahn, U.K., M. Alex, C.-P. Czerny, R. Böhm, W. Beyer (2004): Protection of mice against challenge with Bacillus anthracis STI spores after DNA vaccination. Int. J. Med. Microbiol., 294: 35-44.
  45. Nübel, U., P.M. Schmidt, E. Reiß, R. Bier, W. Beyer, D. Naumann (2004): Oligonucleotide microarray for identification of Bacillus anthracis based on intergenic transcribed spacers in ribosomal DNA. FEMS Microbiol. Lett., 240:215-223.
  46. Beyer, W., C. Bartling, H. Neubauer (2003): Zum Stand der Nachweisverfahren für Bacillus anthracis in klinischen und Umweltproben. Tierärztliche Umschau, 58:653-662.
  47. Garmory, H.S., R.W. Titball, K.F. Griffin, U. Hahn, R. Böhm, W. Beyer (2003): Salmonella enterica serovar Typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect. & Immun., 71:3831-3836.
  48. Müller-Schollenberger, V., W. Beyer, P. Schitzler, A. Merckelbach, S. Roth, B.H. Kalinna, R. Lucius (2001): Immunisation with Salmonella typhimurium-delivered glyceraldehyde-3-phosphate dehydrogenase protects mice against challenge infection with Echinococcus multilocularis eggs. Int. J. Parasitol., 31:1441-1449.
  49. Beyer, W., S. Pocivalsek, R. Böhm (1999): Polymerase chain reaction-ELISA to detect Bacillus anthracis from soil samples – limitations of present published primers. J. Appl. Microbiol., 87:229-236.
  50. Beyer, W. und R. Böhm (1999): Der Einsatz von molekularen Fingerprinttechniken in der Umwelthygiene. Berl. Münch. Tierärztl. Wschr., 112:1-9.
  51. Beyer, W. F.M. Mukendi, P. Kimmig, and R. Böhm (1998): Suitability of Repetitive-DNA-Sequence-Based PCR Fingerprinting for Characterizing Epidemic Isolates of Salmonella enterica Serovar Saintpaul. J. Cinic. Microbiol., 36:1549-1554.
  52. Beyer, W. und R. Böhm. (1996): Labeling Salmonella live vaccine strains with the lux operon from Vibrio fischeri improves their detection and discrimination from wild type. Microbiol. Res., 151:1-13.
  53. Beyer, W., Glöckner, P., Otto, J., Böhm, R. (1995): A nested PCR method for the detection of Bacillus anthracis in environmental samples collected from former tannery sites. Microbiol. Res., 150:1-8.
  54. Schlüter, H., Chr. Beyer, W. Beyer, I. Hagelschuer, L. Geue, P. Hagelschuer. Epidemiologische Untersuchungen zu Salmonelleninfektionen in der Geflügelproduktion. (1994): Tierärztl. Umschau, 49:400-410.
  55. Beyer, W., L. Geue (1992): Characterization of the virulence regions in the plasmids of three live Salmonella vaccines. Zentralblatt für Bakteriologie, 277:10-21.
  56. Beyer, W., B. Drescher, R. Möhring, U. Nötzel, S. Rosenthal. (1987): Molecular cloning of an endogenous cat retroviral element (ECE1) - a recombination between RD 114 and ReLV-related sequences. Archives of Virology, 96:297-301.
  57. Nötzel, U., Jantschak, J., Nyakatura, G., Prösch, S., Beyer, W., Drescher, B., Rosenthal, S., Rosenthal, H.A. (1987): Cloning and characterization of recombinants of bovine leukosis virus (BLV) from BLV-infected fetal lamb kindney cells. Arch. Experim. Veterinarmedizin, 41:697-702.
  58. Tönhardt, H., Beyer, W., Schülke, B. (1986): Methode zur schonenden Isolierung von bovinen Spermienköpfen und –schwänzen. Arch. Experim. Veterinärmedizin, 40:277-283.
  59. Tönhardt, H., Beyer, W., Trautsch, C., Schülke, B. (1986): Zum Vorkommen von Calmodulin in Seminalplasma, Spermienköpfen und –schwänzen vom Rind. Arch. Experim. Veterinärmedizin, 40:284-293.

 

 

 

Oral and poster presentations on occasion of international conferences

 

  1. Hassim A, Dekker EH, Beyer W, Schalkwyk L van, Heerden H van. Isolation of Bacillus anthracis from pachyderms in Kruger National Park, South Africa (2019): ETOSHA Symposium 2019. 112 years and counting… Namibia, June 11 to June 14, 2019.
  2. Beyer W. Scavengers and predators, blue flies, soil and waterholes, and more than 90 different genotypes of Bacillus anthracis. The epidemiology of Anthrax in the Etosha National Park and beyond (2019): ETOSHA Symposium 2019. 112 years and counting… Namibia, June 11 to June 14, 2019.
  3. Beyer W., Hartmann O., Lehrer R.I., Welkos S. (2017): Killing activity and protective efficacy of recombinant gamma-phage lysin and synthetic theta defensins against Bacillus anthracis. Centennial Celebration of Bacteriophage Research, Tbilisi, Georgia, June 26-29, 2017, abstract book p. 24.
  4. Beyer W., van Heerden H., Basson L., Nalisa M. (2016: What we believe to know about the role of flies in the epidemiology of anthrax. The Biology of Anthrax Conference, Tampa, Florida, USA,12th – 15th November 2016. Collection of abstracts, p. 56.
  5. Ndumnego O.C., Koehler S., Crafford J., Beyer W., van Heerden H. (2015): Comparing immunogenicity of non-living anthrax vaccine candidates in combination with simultaneous antibiotic treatment in goats. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Oct. 27-31, 2015, New Dehli, India, abstract book S8.1, p37.
  6. Ndumnego O.C., Koehler S., Buyuk F., Celebi O., Otlu S., Doganay M, Sahin M, Crafford J., Beyer W., van Heerden H. (2015): Using a passive mouse protection model as substitute for direct lethal anthrax challenge in target animals. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Oct. 27-31, 2015, New Dehli, India, abstract book 67.C, p77.
  7. Ntui, B. and Beyer, W. (2014): Treatment of soil with L-Alanin and Inosin as germinants may drop the number of living cells of Bacillus anthracis below an infectious dose level. Workshop on the biology of anthrax, Cardiff, Wales, 11-12 March 2014, abstract book available from Les Baille, School of Pharmacy & Pharmaceutical Sciences, Cardiff University.
  8. Koehler, S. M., Sahin M., Doganay, M., Ndumnego, O., Buyuk, F., Celebi, O.,  Otlu, S., van Heerden, H., and Beyer, W. (2014): Recombinant peptides and FIS tested as vaccine candidates for immunogenicity and protectiveness in farm goats. Workshop on the biology of anthrax, Cardiff, Wales, 11-12 March 2014, abstract book available from Les Baille, School of Pharmacy & Pharmaceutical Sciences, Cardiff University.
  9. Grass G, Klee SR, Beyer W, Wagner DM, Pearson T, Reischl U, Sandven P, Kjerulf A, Hanczaruk M, Keim PS, Grunow R (2013): Genotyping of Bacillus anthracis Strains from an Extended Outbreak of Injectional Anthrax in Drug Consumers. Medical Biodefense Conference 2013, Munich, 22 - 25 October 2013, abstract book, GO 04, p. 15.
  10. Gentile B, Ciammaruconi A, Hilss K, Haumacher R, Pittiglio V, Antwerpen MH, Grass G, Hanczaruk M, Lista F, Beyer W (2013): Towards a Unified Bacillus anthracis MLVA-Typing System: Characterization of Repeat Number and Consensus Sequences of MLVA31 loci. Medical Biodefense Conference 2013, Munich, 22 - 25 October 2013, abstract book, GO 05, p. 15.
  11. Steinmetzer, T., Hardes, K., Lu, Y., Garten, W., Köhler, S., Beyer, W., Sandvig, K., Dahms, S., Than, M. (2013): Highly potent inhibitors of the proprotein convertase furin as potential drugs for the treatment of viral and bacterial infectious diseases. DPHG Annual Meeting 2013, Drug discovery inspired by nature, October 9-11, University Freiburg, conference book MC.78, p. 209.
  12. Ndumnego O., Koehler S., Crafford J., Beyer W. , van Heerden H. (2013): Immunogenicity and protective efficacy of the Sterne 34F2 live spore anthrax vaccine in goats. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Sept. 1-5, 2013, Victoria, Canada, BC, abstract book 90C, p. 93.
  13. Koehler S.M., Huwar T., Baillie L., Beyer W. (2013): Vaccination of NMRI mice against Bacillus anthracis using DNA-vectors and novel adjuvants as an approach to a new acellular vaccine-combination. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Sept. 1-5, 2013, Victoria, Canada, BC, abstract book S9:4, p. 46.
  14. Von Terzi B., Turnbull P.C.B., Beyer W. (2013): Bacillus anthracis does not replicate and survive in the blowfly Calliphora vicina. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Sept. 1-5, 2013, Victoria, Canada, BC, abstract book 42C, p. 70.
  15. Ndumnego O., Koehler S., Crafford J., Beyer W. , van Heerden H. (2013): Quantitative anti-anthrax IgG ELISA correlates with the anthrax toxin neutralization assay in goats. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Sept. 1-5, 2013, Victoria, Canada, BC, abstract book 95B, p. 95.
  16. Grass G., Klee S.R., Beyer W., Wagner D.M., Pearson T., Grunow R., Reischl U., Hanczaruk M., Keim P. (2013): Thirteen Years of Injectional Anthrax in Drug Consumers- Genotyping of Bacillus anthracis Strains from an Ongoing Outbreak. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Sept. 1-5, 2013, Victoria, Canada, BC, abstract book S6:7, p. 39.
  17. Koehler S.M., Sahin M., Otlu S., Doganay M., Ndumnego O., van Heerden H., Beyer W. (2013): Recombinant acellular vaccines tested in goats for immunogenicity and protectivity. The International Conference on Bacillus anthracis, B. cereus, and B. thuringiensis, Sept. 1-5, 2013, Victoria, Canada, BC, abstract book 79A, p. 87.
  18. Getz, W. M.,  S. Bellan, W. Beyer, C. Cizauskas, C. Cloete, H. Ganz, Z. Havarua, P. Imologhome, P. Kamath, W. Kilian, J. Klumpp, M. Küsters, C. Law,  A. Lyons, O. Spiegel, M. Tsalyuk, W. Turner, R. Vance, R. Zidon (2013). Anthrax in Etosha Namibia and lessons for/from elsewhere. Ecology and Evolution of Infectious Diseases (EEID) Conference, University of Georgia, Athens, Georgia, USA; March 15.-18.2013.
  19. Hilss, K.A. and Beyer, W. (2011): SNR analysis for subtyping Bacillus anthracis- an improved methodical approach. International Conference on Bacillus anthracis, B. cereus and B. thuringiensis. Bruges, Belgium, abstract book p. 143.
  20. Koehler, S., Huwar, T.,Baillie, L., and Beyer, W. (2011): Vaccination of NMRI mice against Bacillus anthracis using DNA and protein based acellular vaccine candidates and novel adjuvants. International Conference on Bacillus anthracis, B. cereus and B. thuringiensis. Bruges, Belgium, abstract book p. 185.
  21. Haumacher, R., Hilss, K., Lazak, J., Eberle, G., Kilian, W., Ganz, H., Turner, W., Bellan, S., Getz, W. M., Turnbull, P.C.B., Beyer, W. (2011): Distribution and Evolution of genotypes of Bacillus anthracis in the wildlife of the Etosha National Park and their correlation to outbreaks in farm animals. International Conference on Bacillus anthracis, B. cereus and B. thuringiensis. Bruges, Belgium, abstract book p. 148.
  22. Hilss, K.A; Lazak, J. and  Beyer, W. (2011): Stability testing of three genotyping methods used for Bacillus anthracis International Conference on Bacillus anthracis, B. cereus and B. thuringiensis. Bruges, Belgium, abstract book p. 139.
  23. Klee, S. R., M. Elschner, W. Beyer, R. Grunow (2011): Three cases of anthrax in German heroin user. International Conference on Bacillus anthracis, B. cereus and B. thuringiensis. Bruges, Belgium, abstract book p. 146.
  24. Beyer, W., O. Plajer-Kloess, J. Jedermann, U. K. Hahn, R. I. Lehrer, S. Welkos, and R. Böhm (2009). Killing activity and protective efficacy of recombinant -phage lysin and synthetic theta defensins against Bacillus anthracis. Oral presentation and abstract at Biodefense Conference, München, 20.-22. October, Suppl. to MCIF, 4/2009, HV47, p. 18.
  25. Hilss, K. A., B. Gentile, R. Böhm, F. Lista and W. Beyer (2009). Correlation of the epidemiological information between SNP- and MLV-Analysis. Poster and abstract at Biodefense Conference, München, 20.-22. October, Suppl. to MCIF, 4/2009, EP113, p. 29.
  26. Welkos, S., C. Cote, U. Hahn, O. Hartman, J. Bozue, R. Ruchala, R. Lehrer, W. Beyer (2009): Theta defensins potect mice infected by Bacillus anthracis spores. Poster atBacillus anthracis, B. cereus and B. thuringiensis International Conference, August 30 – September 3, Santa Fe, USA, Abstract book, p. 85.
  27. Satorov, S., M. Rahmatdzhonov, W. Beyer, G. Akhmedova, S. Kholnazarov, kA. Samadov, K. Saidov, R. Rasulov, T. Torok (2009): PCR-analysis and genotyping of B. anthracis strains isolated in Tajikistan. Poster atBacillus anthracis, B. cereus and B. thuringiensis International Conference, August 30 – September 3, Santa Fe, USA, Abstract book, p. 48.
  28. Beyer, W., J. Lazak, K. Hilss, R. Böhm (2009): Stability tests of 31 VNTR markers in routine diagnostics. Poster atBacillus anthracis, B. cereus and B. thuringiensis International Conference, August 30 – September 3, Santa Fe, USA, Abstract book, p. 45.
  29. Beyer, W. (2009): Duration of humoral and cellular immune responses in sheep after immunisation against anthrax, with different recombinant plasmids. Oral pres. at Workshop on the immunology of anthrax, 16th-17th March, 2009, Cardiff University, Cardiff, UK.
  30. Hahn, U., C. Cote, O. Hartman, R. Lehrer, P. Ruchala, W. Beyer, S. Welkos (2008): Novel defensin-like peptides have in vivo protective and therapeutic efficacy against infection with Bacillus anthracis. Poster at 108th ASM General Meeting, June 1-5, 2008, Boston, Massachusetts
  31. Beyer, W. (2008): Anthrax - Epidemiology, Diagnostics, Therapy, and Prophylaxis: Current Knowledge and new Developments. Oral pres. at First Swiss Microbial Safety Meeting, Bellinzona, CH, 4th - 5th September, 2008.
  32. Hartmann, O., U. K. Hahn, R. Böhm, S.H.E. Kaufmann, and W. Beyer (2007): In vitro and in vivo bactericidal activities of recombinant -phage lysins as well as alpha and theta defensins. Oral presentation atBacillus anthracis, B. cereus and B. thuringiensis International Conference, June 17.-21., Oslo, Norway; Abstract book, p. 57.
  33. Boll, K., U. K. Hahn, R. Böhm, and W. Beyer (2007): Recombinant  phage lysin as a substitute for the Bacillus anthracis phage in anthrax diagnostics and as a potential therapeutic agent against anthrax infection in rodent infection models. Poster atBacillus anthracis, B. cereus and B. thuringiensis International Conference, June 17.-21., Oslo, Norway, Abstract book, p. 87.
  34. Hebenstreit, N., U. K. Hahn,  R. Böhm, and W. Beyer (2007): Comparison of the dicriminatory power of Multi-Locus-VNTR-Analysis using eight, fifteen, twenty five or thirty one different markers. Poster atBacillus anthracis, B. cereus and B. thuringiensis International Conference, June 17.-21., Oslo, Norway, Abstract book, p. 64.
  35. Beyer, W., U. Hahn, R. Böhm (2005): DNA vaccination protects outbred mice against a lethal infection with Bacillus anthracis. Poster und Abstract. New Approaches to Vaccine Development – From the bench to the field. Berlin, 8.-10. September, 2005.
  36. Beyer, W. (2005): Anthrax:Molecular Techniques - Advantages and Pitfalls. Vortrag zum Workshop to formulated prepardness & action plans for Anthrax epizootics in wildlife zones. 24.-28. October, 2005, Malilangwe, Zimbabwe.
  37. Beyer, W., U. Hahn, M. Aichler, R. Boehm (2005): Comparison of immune responses and their duration after DNA vaccination against anthrax in sheep. Poster at Bacillus anthracis, B. cereus and B. thuringiensis International Conference, Sept. 27.-29., Santa Fe, USA, Abstract book, p. 49.
  38. Beyer, W.; U.K. Hahn, R. Boehm (2005): Lipopeptide adjuvant versus aluminium hydroxide in PA based vaccines. Poster at Bacillus anthracis, B. cereus and B. thuringiensis International Conference, Sept. 27.-29., Santa Fe, USA, Abstract book, p. 49.
  39. Hahn, U., and W. Beyer (2004): DNA vaccination against anthrax - Combination of anti-spore and anti-toxin components. Poster und Abstract zur Medizinischen B-Schutztagung, 21.-22. Oktober, München.
  40. Beyer, W., U. Hahn, R. Boehm (2004): Protection of mice against challenge with Bacillus anthracis spores after DNA vaccination. Poster und Abstract zum 11th International Congress of Infectious Diseases, Abstract in: Int. J. Infect. Dis., 11th ICID Abstracts, 8:222.
  41. Beyer, W., U. Hahn, R. Böhm (2004): DNA vaccination against anthrax in mice – Combination of anti-spore and anti-toxin components. Poster and Abstract at The gene vaccine conference, 17.-19. November 2004, Monte Carlo, Monaco.
  42. Hahn, U., M. Aichler, R. Böhm, W. Beyer (2004): Comparison of the immunological memory after DNA vaccination and protein vaccination against anthrax in sheep. Poster und Abstract at The gene vaccine conference, 17.-19. November 2004, Monte Carlo, Monaco.
  43. Beyer, W. and R. Böhm (2003): Pitfalls in the diagnois of B. anthracis from environmental samples – lessons from investigations of suspicious specimens. Vortrag zum XI. Int. Congress in Animal Hygiene. 23.-27. Feb. 2003, Mexico City, Beitrag publiziert in Proceedings, ISBN-970-93539, pp. 413-420.
  44. Beyer, W., U. Hahn und R. Böhm (2003): Versuche zur Testung rekombinanter Vakzine-Kandidaten gegen die Milzbrandinfektion in kleinen Labortieren. Poster und Vortrag zur Medizinischen B-Schutz-Tagung, München, 29.-30.10.2003.
  45. Beyer, W., U. Hahn, and R. Böhm (2003): Anthrax – Diagnosis and Prophylaxis. Vortrag zur Int. Conference of Anthrax, Vieste, Italien, 10.-11.10.2003.
  46. Beyer, W., U. Reischl, V.G. DelVecchio, and R. Böhm (2003): Pitfalls in the diagnosis of B. anthracis from environmental samples – lessons from the investigation of “Suspicious Specimens”. Poster at 5th Int. Conference on Anthrax. 30.03.-03.04.2003, Nizza, Abstract book, p. 68.
  47. Hahn, U., W. Beyer, and R. Böhm (2003): Protection of mice against challenge with Bacillus anthracis spores after DNA vaccination. Poster at 5th Int. Conference on Anthrax. 30.03.-03.04.2003, Nizza, Abstract book, p. 78.
  48. Beyer, W., K.E. Griffin, H.S. Garmory, R.W. Titball, and R. Böhm (2003): Development of live recombinant Salmonella vectors as vaccine candidates against B. anthracis. Poster at 5th Int. Conference on Anthrax. 30.03.-03.04.2003, Nizza, Abstract book, p. 81.
  49. Beyer, W., U. Hahn, K.E. Griffin, H.S. Garmony, U. Green, R.W. Titball, and R. Böhm (2001): Improvements in the development of live Salmonella vectors for the delivery of vaccine candidates against B. anthracis. Poster at 4th International Conference on Anthrax. Annapolis, USA, 10.-13. June, 2001, Abtract book. p. 47.
  50. Griffin, K.F., H.S. Garmory, A. Siddall, R.W. Titball, and W. Beyer (2001): Immune Responses and Protective Efficacy of Novel Salmonella-based Vaccines Expressing the Protective antigen of Bacillus anthracis. Poster zur 7th International Antibody Conference on Targeted Cellular Toxicity. UK.
  51. Beyer, W., B. Weber, R. Böhm (2000): Development of procaryotic and eucaryotic exresssion cassettes and recombinant life Salmonella vectors as vaccines against Anthrax. Poster at 2nd International Veterinary Vaccines and Diagnostics Conference. Oxford, 23-28 July, 2000, Abstract book. p. 91.
  52. Beyer, W., B. Weber, R. Böhm (1999): Konstruktion und Prüfung rekombinanter prokaryontischer und eukaryontischer Expressions-Kassetten mit dem protektiven Antigen von B. anthracis. Vortrag zur 6. Medizinische B-Schutz-Tagung des BMVg, 27. – 28.10.99, München.
  53. Beyer, W. and R. Böhm (1997): Genetic labeling of Salmonella live vaccines with the lux operon from Vibrio fischeri. Poster at First International Veterinary Vaccines and Diagnostics Conference. Madison, Wisconsin (USA), 27.-31.7, 1997, Abstract book p. 91.
  54. Beyer, W., C. Müller, R. Böhm (1997): Molecular typing of E. coli for detecting sources of fecal pollution of groundwater. Poster zum 9th International Congress in Animal Hygiene, 17.-21. August 1997, Helsinki, Finland, publziert in: Proceedings Vol. 2, 852-855, ISBN 951-45-7802-3, pp. 852-855, pp. 757-760.
  55. Beyer, W., F. Mukendi, R. Böhm (1997): Molecular typing of Salmonellasaint-paul related to an outbreak in southern Germany. Poster zum 9th International Congress in Animal Hygiene, 17.-21. August 1997, Helsinki, Finland, publiziert in: Proceedings Vol. 2, 757-760, ISBN 951-45-7802-3.
  56. Hafez, H.M. und W. Beyer (1997): Preliminary invetigation on ornithobacterium rhinotracheale „ORT“ isolates using PCR-Fingerprints. Vortrag und Abstract in: Proceedings of XIth International Congress of the World Veterinary Poultry Association, Budapest, S. 51.
  57. Beyer, W., Glöckner, P., Otto, J., Böhm, R. (1995): A nested PCR method for the detection of Bacillus anthracis in environmental samples collected from former tannery sites. Vortrag zum 7th International Symposium on Microbial Ecology, 27.08.-01.09.1995, Santos, Brazil, Abstract book, p. 66.
  58. Beyer, W., P. Glöckner, J. Otto, R. Böhm (1995): "Nested PCR" und "DNA-Amplification-Fingerprinting" (DAF) zum Nachweis von Bacillus anthracis aus Bodenproben ehemaliger Gerbereistandorte. Poster zum 21. Kongreß der DVG, Bad Nauheim, 21.-24. 3. 1995, Kongreßbericht in: Die Deutsche Bibliothek. ISBN 3-930511-12-6. Teil II, 22-34.
  59. Müller, V., Beyer, W., Seidinger, S., Schitzler, P., Merckelbach, A., Lucius, R. (1995): Immunization with a recombinant antigen of Echinococcus multilocularis expressed in Salmonella Typhimurium reduces the parasite burden of mice after oral infection. Vortrag zum Spring Meeting of the British Society for Parasitology, 10.-12. April 1995, Univ. of Edinburgh.
  60. Beyer, W., G. Meixner, R. Böhm (1994): Detection of Salmonella spp. by nested polymerase chain reacion in liquid manure and biocompost. Vortrag zum 8th International Congress on Animal Hygiene. 12.-16. September, 1994, St. Paul, Minnesota, publziert in: Proceedings of the 8th Int. Congress on Animal Hygiene.
  61. Schlüter, H., Chr. Beyer, W. Beyer, I. Hagelschuer, L. Geue (1992): Salmonella surveillance program in big poultry farms. Poster zum Int. Symposium, 15.-17.9.1992, Ploufragan, Frankreich.
  62. Beyer, Chr., H. Schlüter, W. Beyer (1992): Salmonella-Monitoring in großen Geflügelbeständen. Vortrag zum 4. Hohenheimer Seminar: Aktuelle Zoonosen, publiziert in Deutsche Bibliothek. ISBN 3-924851-68-9:41-47.
  63. Schlüter H., Chr. Beyer, W. Beyer, I. Hagelschuer, L. Geue (1992): Epidemiologische Untersuchungen in großen Geflügelanlagen am Beispiel der Infektion mit unterschiedlichen S.-Serovaren. Vortrag zum 3rd World Congress Foodborne Infections and Intoxications, 16.-19. 6. 1992. Berlin.
  64. Beyer, W., L. Geue (1991): Characterization of the virulence regions in the plasmids of three live Salmonella vaccines. WHO Working Group on Salmonella Immunization in Animals. Jena, FRG, 17.-21.6.1991
  65. Beyer, W., L. Geue (1990): Molekulare Klonierung einer Virulenzdeterminante aus einem 96 kb-Virulenzplasmid von S. typhimurium. Poster zum XI. Kongreß der Gesellschaft für Mikrobiologie und Epidemiologie der DDR, 5.-8. März 1990, Erfurt.
  66. Drescher, B., R. Möhring, W. Beyer, S. Prösch (1987): Structure of the long terminal repeat from endogenous cat virus RD 114. Poster zum XVIIth Meeting of the European Tumour Virus Group, September 21-26, 1987, Dresden.
  67. Möhring, R., B. Drescher, W. Beyer, E. Grau (1987): Nucleotide sequence and expression in E. coli of the transmembrane protein coding region of both RD 114 virus and an endogenous cat retroviral element ECE1. Poster zum XVIIth Meeting of the European Tumour Virus Group, September 21-26, 1987, Dresden.
  68. Möhring, R., B. Drescher, W. Beyer (1987): Comparative studies on the structure of the LTR and the genes coding for transmembrane proteins of endogenous feline retroviruses. Vortrag zur Tagung Problems of Molecular Biology and Immunochemistry, 15.-17.4.1987, Riga.

 

 

Patent

Beyer, W. (1997). Salmonella-Lebendimpfstoff. Patent Nr.: 4425382 C 2, Deutsches Patentamt, Tag der Anmeldung: 19.07.1994.